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![]() Hence, there is a significant knowledge gap with respect to the metabolic perturbations induced by engineered nanomaterials on phytoplankton, despite their pivotal role in global biogeochemical cycles and food-web dynamics 13. Regarding phytoplankton, only one metabolomic study focused on the effect of silver nanoparticles (AgNPs) on cyanobacterium Microcystis aeruginosa 12. The perspectives and challenges in the application of metabolomics to understand the nanotoxicology of plants have recently been comprehensively reviewed 10, 11. Nanoparticle-induced metabolic perturbations to environmentally relevant organisms, such as plants, have only been recently studied systematically by both untargeted and targeted metabolomics 4– 9. It is well suited to study organism–environment interactions 3 and serves to integrate information on metabolic pathway perturbation with physiological responses to stressors. Metabolomics tracks the changes in low-molecular-weight metabolites involved in different biological reactions 1, 2 under different environmental stimuli and stressors. We highlight the potential of metabolomics as a tool for understanding the molecular basis for these metabolic and physiological changes, and for early detection of stress. The metabolic perturbations corroborate the observed physiological responses. #Normalization in graphpad prism 8 driver#The results suggest that dissolved Ag ions released by AgNPs are the major toxicity driver however, AgNPs internalized in food vacuoles contributed to the perturbation of amino acid metabolism, TCA cycle and oxidative stress. We show time-dependent perturbation of the metabolism of amino acids, nucleotides, fatty acids, tricarboxylic acids, photosynthesis and photorespiration by both Ag-treatments. We combine targeted metabolomics, biouptake and physiological response studies to elucidate metabolic perturbations in alga Poterioochromonas malhamensis induced by AgNPs and dissolved Ag. Despite progress in assessing their environmental implications, knowledge gaps exist concerning the metabolic perturbations induced by AgNPs on phytoplankton, essential organisms in global biogeochemical cycles and food-web dynamics. Exclude all files.Silver nanoparticles (AgNPs) are one of the most used engineered nanomaterials.Also, turn off automatic checking of updates from Setup. #Normalization in graphpad prism 8 update#
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